Cellulose — in particular, cellulose in “lignocellulosic biomass” — embodies a great dream of the bioorganic chemist, that of harnessing the enormous power of nature as the renewable source for all the chemicals needed in a modern, biosciencebased economy.1 From that perspective, the future is not one of petroleum crackers and industrial landscapes fi lled with the hardware of synthetic organic chemistry, but a more ecofriendly one of microbes and plant and animal cells purpose-dedicated to the large-scale production of antibiotics and blockbuster drugs, of monomers for new biodegradable plastics, for aromas, fragrances, and taste stimulators, and of some (if not all) of the novel compounds required for the arrival of nanotechnologies based on biological systems. Glucose is the key starting point that, once liberated from cellulosic and related plant polymers, can — with the multiplicity of known and hypothesized biochemical pathways in easily cultivatable organisms — yield a far greater multiplicity of both simple and complex chiral and macromolecular chemical entities than can feasibly be manufactured in the traditional test tube or reactor vessel.
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